Jul 14, 2021 · slowed breathing. confusion. slurred speech. unusual bruising. extreme sleepiness. yellowing of the skin or eyes. dark-colored urine. light-colored stools. Serious side effects after taking Subutex may be a sign of a Subutex allergy, drug misuse, or an unsuitable dosage. Jun 3, 2022 · The initial recommended Subutex dose or dosage ranges from 0.8 mg to 4 mg, taken once a day. Then, the Subutex dosage can increase based on the effects of the drug, but this should be done under close clinical supervision. It’s not recommended that anyone exceed a daily Subutex dose of more than 32 mg. Then, the Subutex dosage can gradually ... Your doctor can help you create a plan for safely making the transition from methadone to buprenorphine. Steps for switching to Subutex: 1. Tapering Your Methadone Dosage. To transition to buprenorphine, you’ll need to gradually taper the amount of methadone you are taking to either a very low dose or abstinence.BUPRENORPHINE treats opioid use disorder. It works by reducing withdrawal symptoms and cravings to use opioids. It is most effective when used in combination with counseling and behavior therapy. Get buprenorphine for as low as $49.89, which is 91% off the average retail price of $560.61 for the most common version, by using a GoodRx coupon.4. Bottom Line. Subutex was a brand name of sublingual buprenorphine, but it has been discontinued. Suboxone, which contains buprenorphine and naloxone, may be used instead. 5. Tips. Subutex sublingual tablets were used as part of a complete treatment plan that included counseling and psycho-social support.In conclusion, a transfer from Subutex to Suboxone should be carefully discussed and planned in advance with the patients and after the transfer adverse events should be regularly monitored. With regard to buprenorphine abuse, the combination product seems to have a more favorable safety profile than treatment with buprenorphine alone.Generally, symptoms start within 48 hours after the last dose and peak around day three. Some patients experience mental health symptoms like anxiety, fatigue, sleep issues, mood swings and drug cravings for weeks or months after opioid/Suboxone use, which is known as Post-Acute Withdrawal Syndrome (PAWS). A slow taper off of …6 days ago · Addiction Treatment with Subutex (Buprenorphine) In 2017, more than 47,000 Americans died from an opioid overdose. 7 In the same year, 1.7 million people in the U.S. were estimated to struggle with an opioid use disorder involving prescription painkillers. 7 Prescription opioid diversion and misuse puts the lives of millions of people at risk; however, medications like buprenorphine are ... Some forms of buprenorphine can be used to provide pain relief because activating mu-opioid receptors also relieves pain. Sublocade belongs to the class of medicines known as narcotic analgesics. It may also be called an opioid analgesic. Sublocade is only used for the treatment of opioid (narcotic) addiction. 2.This is the time it takes for half of the drug to be metabolized and eliminated in the body. The elimination half-life of buprenorphine is 24 to 42 hours Generally, it takes four to five half-lives for a drug to be eliminated from the body. In most healthy people, no trace of Subutex would have been found after 120 to 210 hours (5 to 8 days).Buprenorphine is a sublingually and transdermally available, semisynthetic opioid analgesic, which is used as an analgesic and for management of opioid dependence. Therapy with buprenorphine is associated with mild and transient serum enzyme elevations, and with moderate-to-severe clinically apparent liver injury when abused by …buprenorphine + pimozide. contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects) potassium chloride. Subutex (buprenorphine) +. potassium chloride. 1 interaction.The main difference is that Suboxone contains both buprenorphine and naloxone, whereas Subutex contains only buprenorphine. Suboxone and Subutex are both brand names. While both drugs were developed at around the same time, Subutex was formulated first and while it was found to be relatively effective in the treatment of opiate addiction, there ...Getting your MFA could get you started on the pathway to a career in the arts. Learn about how getting your MFA works at HowStuffWorks. Advertisement Have you ever been moved by a ...Subutex is less tightly controlled than methadone, and this is largely because it’s seen as less addictive and dangerous. Methadone has to be given in clinics, while people can receive an at-home prescription for Subutex, as long as their doctor is certified to administer it. Buprenorphine, which is the active ingredient in Subutex, …The dosage of Subutex 8 mg is frequently discussed, specifically. Subutex 8 mg is the highest individual dose of a single Subutex pill. It’s a sublingual tablet, and as … Buprenorphine is an opioid medication. Buprenorphine oral/sublingual (given under the tongue) is used to treat opioid addiction. Other forms of buprenorphine are used to treat moderate to severe pain. Buprenorphine is more effective than clonidine or lofexidine for managing opioid withdrawal in terms of severity of withdrawal, duration of withdrawal treatment, and the likelihood of treatment completion. Buprenorphine and methadone appear to be equally effective, but data are limited.Jan 15, 2024 · What Do Suboxone/Buprenorphine Pills Look Like? Reviewed By Peter Manza, PhD • Updated Jan 15, 2024 • 3 cited sources. Table of Contents. How To Recognize Them. How To Get Treatment. Brand-name Suboxone tablets or pills are small, orange, and hexagonal. They contain both naloxone and buprenorphine, and they’re marked accordingly. Written by Sarah Stasik Updated: December 2, 2020. Subutex is used in the treatment of drug addiction. It’s a name-brand form of buprenorphine, and both buprenorphine and Subutex are approved by the Food and Drug Administration for use in opioid addiction treatment.In 40.7% of cases of heroin addiction treatment and 36.4% …This medicine is given as a shot under your skin, into a muscle, or into a vein. It is very important that you understand the requirements of the Brixadi™ and …Common buprenorphine medications include Suboxone®, Zubsolv®, and Subutex®. Use this guide to help describe what you were taking to your clinician. Remember: Non-prescription/street medications carry the increased risk of containing fentanyl or other dangerous substances, increasing the risk of overdose or a bad reaction.Answers. there isnt a difference. I don't know this but I suspect you may have seen the relatively new generic version of subutex. I looked on here and couldn't find a photo of the generic version, but know there is one and that it is probably only a year or less old. Wikipedia.org may have a photo, let me see if I can find it really quick.In honor of evil week, we're going to shift gears from picking the best of something to the worst of something. We know you have strong feelings about which companies offer some pr...Along with its needed effects, buprenorphine (the active ingredient contained in Subutex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. ... Subutex 8 mg (B8 Logo) View larger images. Drugs.com Mobile Apps. The easiest way to lookup drug information, …Both Suboxone and Subutex also have the active ingredient buprenorphine, which is a partial opioid agonist. The key difference between Suboxone and Subutex is that Suboxone has naloxone. Naloxone helps prevent abuse of Suboxone by blocking opioid effects if someone tries to inject or snort it to get high.SUBUTEX® (Sub-u-tex) (buprenorphine) Sublingual Tablet (CIII) Keep SUBUTEX in a secure place away from children. Accidental use by a child is a medical emergency and …The "B8" imprint indicates that it is an 8 mg strength buprenorphine tablet. Tablet (8 mg): A white, hexagonal-shaped pill with "54 411" imprinted on one side. The "54 411" imprint indicates that it is an 8 mg strength buprenorphine tablet. Generic Subutex. Generic Subutex tablets are available in 2 mg and 8 mg strengths.May 17, 2023 · Subutex is still available in other parts of the world, and generic forms of sublingual buprenorphine are available in the United States. Subutex is a brand name of buprenorphine, a drug approved by the FDA in 2002 as a treatment for opioid use disorder. Buprenorphine is a type of medicine called a partial opioid agonist. Medication Assisted Treatment Program. Our MAT Program combines behavioral therapy with Suboxone or Subutex to treat substance use disorders. Our comprehensive approach allows our doctors to treat the underlying traumas and causes of substance abuse while preparing patients for the life long process of long term recovery from addiction.Buprenorphine is a generic prescription drug classified as a partial opioid agonist. It is used along with drug counseling and other measures to treat OUD. Suboxone is a brand-name drug used alongside counseling to treat OUD. It contains two active ingredients: buprenorphine and naloxone.SUBUTEX should be placed under the tongue until it is dissolved. For doses requiring the use of more than two tablets, patients are advised to either place all the tablets at once or alternatively (if they cannot fit in more than two tablets comfortably), place two tablets at a time under the tongue. EitherBuprenorphine, a controlled substance sold under the brand names Subutex and Suboxone, is a medication to treat opioid use disorder. Research shows it halves the risk of overdose and doubles ...4. Bottom Line. Subutex was a brand name of sublingual buprenorphine, but it has been discontinued. Suboxone, which contains buprenorphine and naloxone, may be used instead. 5. Tips. Subutex sublingual tablets were used as part of a complete treatment plan that included counseling and psycho-social support.1. How it works. Subutex was a brand (trade) name for a buprenorphine sublingual product that was available as a tablet and a buccal film. Subutex sublingual …Rp b8 vs 54411 subutex. Just filled my script today and my pharmacy gave me a different brand of subutex I’m used to getting the 544111 and got the rp8 tomorrow I’ll be taking the rp hopefully there’s no change and I’ll only be taking the rp under the tounge as the 54 I was snorting and under the tounge mostly snorting any advice or ...QUICK START GUIDE. Specifically discuss safety concerns: Understand that discontinuing buprenorphine increases risk of overdose death upon return to illicit opioid use. Know that use of alcohol or benzodiazepines with buprenorphine increases the risk of overdose and death. Understand the importance of informing providers if they become pregnant.Suboxone’s optimal function can decrease or become life-threatening when taken in combination with kratom. Coming off of drugs is the goal in recovery. Play it safe and listen to your healthcare professional’s expert opinion. Keep in mind that when powerful drugs are taken together they can have unexpected and undesired effects.Buprenorphine is an opioid medication. Buprenorphine oral/sublingual (given under the tongue) is used to treat opioid addiction. Other forms of buprenorphine are used to treat moderate to severe pain.Buprenorphine is a synthetic opioid developed in the late 1960s and is used to treat pain and opioid use disorder. This drug is a synthetic analog of thebaine—an alkaloid compound derived from the poppy flower. Buprenorphine is categorized as a Schedule III drug, which means it has a moderate-to-low potential for physical dependence or a high potential for psychological dependence ...SIDE EFFECTS: Drowsiness, dizziness, constipation, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist immediately.To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool ...Subutex is less tightly controlled than methadone, and this is largely because it’s seen as less addictive and dangerous. Methadone has to be given in clinics, while people can receive an at-home prescription for Subutex, as long as their doctor is certified to administer it. Buprenorphine, which is the active ingredient in Subutex, …Buprenorphine is an opioid medication. Buprenorphine oral/sublingual (given under the tongue) is used to treat opioid addiction. Other forms of buprenorphine are used to treat moderate to severe pain.Rp b8 vs 54411 subutex Just filled my script today and my pharmacy gave me a different brand of subutex I’m used to getting the 544111 and got the rp8 tomorrow I’ll be taking …Find out why Suboxone, Subutex is prescribed, side effects of Suboxone, Suboxone warnings, effects of Suboxone during pregnancy, more - in plain English. Generic name: Combination of buprenorphine and naloxone Brand name: Suboxone. Pronounced: SUB-ox-own. Additional Suboxone Patient Information Full Suboxone Prescribing …Suboxone Usage. Buprenorphine is itself a semisynthetic opioid that is much less potent than other common drugs of the same class, such as heroin and Vicodin. 1 Taking buprenorphine allows individuals addicted to these other drugs to avoid the intense cravings and withdrawal symptoms that make quitting opiates so difficult. At the same …Who can use buprenorphine. Most adults can use buprenorphine. Children can sometimes use it if a specialist doctor recommends it. Buprenorphine is usually only recommended when weaker opioids for pain stop working for you. Your doctor or pharmacist will work out how much buprenorphine to give you, depending on why you're using it and what dose ... Buprenorphine. Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. [17] It can be used under the tongue (sublingual), in the cheek (buccal), by injection ( intravenous and subcutaneous ), as a skin patch (transdermal), or as an implant. Buprenorphine comes as a sublingual tablet. The combination of buprenorphine and naloxone comes as a sublingual tablet (Zubsolv) and as a sublingual film (Suboxone) to take under the tongue or to apply between the gum and cheek. After your doctor determines an appropriate dose, these products are usually taken once a day.Sep 29, 2023 · No, Subutex should not be initiated with opioids in your system. Subutex needs to be initiated at least 6 to 12 hours, or longer, after the last dose of a short-acting opioid, such as heroin. If taken too soon, Subutex could precipitate premature withdrawal symptoms, because Subutex will rapidly displace any opioid that is occupying a mu ... SUBUTEX or SUBOXONE is administered sublingually as a single daily dose in the range of 12 to 16mg/ day. When taken sublingually, SUBOXONE and SUBUTEX have similar clinical effects and are interchangeable. There are no adequate and well-controlled studies using SUBOXONE as initial medication. SUBUTEX contains no naloxone and is …Results: A total of 240 urine samples from 41 patients were included for this study. The 41 patients received a mean buprenorphine dose of 10.5 ± 3.7 mg/day (range, 4-20 mg/day).Dec 2, 2020 · It’s a name-brand form of buprenorphine, and both buprenorphine and Subutex are approved by the Food and Drug Administration for use in opioid addiction treatment. In 40.7% of cases of heroin addiction treatment and 36.4% percent of cases of treatment for non-heroin opioids in 2017, medications such as buprenorphine were used. This is because naloxone, which is an opioid antagonist, acts as a misuse deterrent by causing precipitated withdrawal if someone injects or snorts their …Jun 11, 2015 · Subutex and Suboxone are drugs that were approved by the FDA in 2002 for the treatment of opioid dependence. Both drugs contain the active ingredient buprenorphine, a semisynthetic opioid that acts as primarily as a partial mu-opioid receptor agonist. Buprenorphine also acts as an antagonist at the kappa and delta opioid receptors. The REMS for Subutex (buprenorphine) sublingual tablets and the REMS for Suboxone (buprenorphine and naloxone) sublingual tablets were originally approved on December 22, 2011. Each REMS was modified on September 22, 2015, to consolidate the three product-specific REMS into a single REMS. Jul 14, 2021 · slowed breathing. confusion. slurred speech. unusual bruising. extreme sleepiness. yellowing of the skin or eyes. dark-colored urine. light-colored stools. Serious side effects after taking Subutex may be a sign of a Subutex allergy, drug misuse, or an unsuitable dosage. What is Sublocade injection? How is Subutex different than suboxone? Suboxone, Subutex, and Sublocade are just different ways of taking the medication Bupre...4. Bottom Line. Subutex was a brand name of sublingual buprenorphine, but it has been discontinued. Suboxone, which contains buprenorphine and naloxone, may be used instead. 5. Tips. Subutex sublingual tablets were used as part of a complete treatment plan that included counseling and psycho-social support.Playlist créée à partir de la lecture de Vernon Subutex de Virginie Despentes.Ce n'est pas vraiment une B.o. du livre mais plutôt un recensement systématique...Answers. there isnt a difference. I don't know this but I suspect you may have seen the relatively new generic version of subutex. I looked on here and couldn't find a photo of the generic version, but know there is one and that it is probably only a year or less old. Wikipedia.org may have a photo, let me see if I can find it really quick.Results 1 - 13 of 13 for " RP b8". Sort by. Results per page. RP b8. Buprenorphine Hydrochloride (Sublingual) Strength. 8 mg (base) Imprint. RP b8.Buprenorphine doses adjustments are often needed during pregnancy, even if the patient has been maintained on a stable dose prior to pregnancy. There are no controlled data in human pregnancy. Opioids cross the placenta and may produce respiratory depression in neonates. This drug is not recommended for use prior to labor, …Sep 29, 2023 · No, Subutex should not be initiated with opioids in your system. Subutex needs to be initiated at least 6 to 12 hours, or longer, after the last dose of a short-acting opioid, such as heroin. If taken too soon, Subutex could precipitate premature withdrawal symptoms, because Subutex will rapidly displace any opioid that is occupying a mu ... These medications may decrease the effects of Suboxone: Some seizure medications, including phenobarbital, Tegretol ( carbamazepine) and Dilantin ( phenytoin) Rifadin ( rifampin ), a treatment for tuberculosis (can increase the metabolism of Suboxone) Revia or Vivitrol (both contain naltrexone) It's important to tell your doctor about …Buprenorphine, a controlled substance sold under the brand names Subutex and Suboxone, is a medication to treat opioid use disorder. Research shows it halves the risk of overdose and doubles ...Jul 14, 2021 · slowed breathing. confusion. slurred speech. unusual bruising. extreme sleepiness. yellowing of the skin or eyes. dark-colored urine. light-colored stools. Serious side effects after taking Subutex may be a sign of a Subutex allergy, drug misuse, or an unsuitable dosage. No, Subutex should not be initiated with opioids in your system. Subutex needs to be initiated at least 6 to 12 hours, or longer, after the last dose of a short-acting opioid, such as heroin. If taken too soon, Subutex could precipitate premature withdrawal symptoms, because Subutex will rapidly displace any opioid that is occupying a mu ...A Reference Listed Drug (RLD) is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application (ANDA). By designating a single reference listed drug as the ...Try to avoid very hairy areas, or trim the hairs first before applying the patch. If you find shaving easier, shave the area a few days before you apply the patch to make sure shaving does not irritate your skin. Press the patch against your skin for at least 30 seconds. Make sure it sticks well, especially the edges.Apr 1, 2024 · Buprenorphine acts on the central nervous system (CNS) to relieve pain. Buprenorphine sublingual tablet is used to treat opioid use disorder. When an opioid medicine is used for a long time, it may become habit-forming, causing mental or physical dependence. Physical dependence may lead to withdrawal side effects if the opioid is stopped suddenly. RP b8. Buprenorphine Hydrochloride (Sublingual) Strength 8 mg (base) Imprint RP b8 Color White Shape Round View details. 1 / 4This is the second such offense in recent months. In case anyone's forgotten that Japan works very differently from most other places, a train company made a public apology this we...May 23, 2014. from U.S.A. Hey there, Although big pharma will never admit it, I strongly believe that you will have a higher bioavailability snorting than using it sublingually. With that said, the method has it's down side. Because it's in the form of HCL, just like cocaine (powder), you will have problems with irritation to the mucus membrane ...RP b8. Color. White. Shape. Round. View details. 54 375. Buprenorphine Hydrochloride and Naloxone Hydrochloride (Sublingual) Strength. 8 mg (base) / 2 mg (base) Imprint.Generic Name Buprenorphine DrugBank Accession Number DB00921 Background. Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of …Subutex is less tightly controlled than methadone, and this is largely because it’s seen as less addictive and dangerous. Methadone has to be given in clinics, while people can receive an at-home prescription for Subutex, as long as their doctor is certified to administer it. Buprenorphine, which is the active ingredient in Subutex, …Subutex (Sublingual) received an overall rating of 9 out of 10 stars from 26 reviews. See what others have said about Subutex (Sublingual), including the effectiveness, ease of use...Suboxone is a prescription medication used in the treatment of opioid use disorder. It is beneficial for treating withdrawal symptoms in the early stages of treatment and for preventing relapse while patients participate in counseling and other services on an ongoing basis. Buprenorphine, the main drug in Suboxone, reduces symptoms of craving ...
Mar 31, 2021 · Subutex is an uncoated tablet intended for sublingual administration. Subutex is supplied as white, oval tablets containing 0.4 mg, 2 mg and 8 mg buprenorphine. Tablets are debossed with either "04", "B2" or "B8" respectively for Subutex 0.4 mg, Subutex 2 mg and Subutex 8 mg. 4 Clinical Particulars. 4.1 Therapeutic Indications . Does susan tran still work at necn
Sep 29, 2023 · No, Subutex should not be initiated with opioids in your system. Subutex needs to be initiated at least 6 to 12 hours, or longer, after the last dose of a short-acting opioid, such as heroin. If taken too soon, Subutex could precipitate premature withdrawal symptoms, because Subutex will rapidly displace any opioid that is occupying a mu ... GTA RP, or Grand Theft Auto Roleplay, has gained immense popularity in recent years. It offers players a unique opportunity to immerse themselves in a virtual world where they can ... Find patient medical information for buprenorphine HCl sublingual on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. (buprenorphine and naloxone) sublingual film or SUBOXONE ® (buprenorphine and naloxone) sublingual tablet is generally initiated after two days of SUBUTEX titration. …Mar 8, 2024 · Buprenorphine is an opioid partial agonist. It produces effects such as euphoria or respiratory depression at low to moderate doses. With buprenorphine, however, these effects are weaker than full opioid agonists such as methadone and heroin. When taken as prescribed, buprenorphine is safe and effective. RP b8 Color White Shape Round View details. 1 / 4 Loading. Logo (Actavis) 153. Previous Next. Buprenorphine Hydrochloride (Sublingual) Strength 8 mg (base) Imprint Logo (Actavis) 153 Color Orange Shape Oval View details. 1 / 2 Loading. 460 . Previous Next. Buprenorphine Hydrochloride (Sublingual) Strength 8 mg (base) Imprint 460 Color White …Buprenorphine is a synthetic opioid, more specifically a partial µ receptors agonist and a κ receptors antagonist. Since 1996, high dosage sublingual forms …Subutex is not generally prescribed alongside other opiates. Taking Subutex with other opioids could exacerbate the respiratory effects of Subutex, which are generally mild when taken alone. Primary dangers of mixing Subutex with other opioids include: overdose. breathing problems. drug relapse. coma. death.Klinic can help you get the addiction treatment and support you need to get sober by connecting you to the best independent Suboxone providers near you. Suboxone is a medication used in medication-assisted treatment (MAT). MAT combines medication with counseling and behavioral therapies and has shown great results in treating opioid …An addiction can appear based on how often the medication is used, the dosage, and the lack of concern for the side effects that Subutex can bring. Some side effects that can occur while taking the drug are: Constipation. Hoarseness. Headaches. Nausea. Painful urination. Vomiting.Generic Name Buprenorphine DrugBank Accession Number DB00921 Background. Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of …May 19, 2012 · May 23, 2014. from U.S.A. Hey there, Although big pharma will never admit it, I strongly believe that you will have a higher bioavailability snorting than using it sublingually. With that said, the method has it's down side. Because it's in the form of HCL, just like cocaine (powder), you will have problems with irritation to the mucus membrane ... Drowsiness, dizziness, constipation, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist right away. To prevent constipation, eat dietary fiber, drink ... The latest developer builds of Google Chrome enable extensions by default, add support for skins, and even improve compatibility with Windows 7. The latest developer builds of Goog...Buprenorphine doses adjustments are often needed during pregnancy, even if the patient has been maintained on a stable dose prior to pregnancy. There are no controlled data in human pregnancy. Opioids cross the placenta and may produce respiratory depression in neonates. This drug is not recommended for use prior to labor, …B2 and B8 Pill. The B2 pill and B8 pill are the same as the N2 and N8 pills. They are orange and hexagonal and contain the same 4 to 1 ratio of buprenorphine to naloxone. B2 contains 2 mg of buprenorphine, while B8 contains 8 mg. Both pills are imprinted with their strength, either B2 or B8. Generic SuboxoneCommon questions about buprenorphine - Brand names: Butec, Buvidal, Espranor, Suboxone, Subutex. How does buprenorphine work? Buprenorphine is from a group of medicines called opioids or narcotics. It works in the central nervous system and the brain to block pain signals to the rest of the body. It also reduces the anxiety and stress …Subutex. Subutex is a sublingual tablet formulation of buprenorphine approved for the treatment of opioid dependence, with a particular focus on the induction phase of treatment. ... Kapil RP, Cipriano A, Michels GH, et al. Effect of ketoconazole on the pharmacokinetic profile of buprenorphine following administration of a once-weekly ...It also blocks the effects of other opioids. Some of the common short-term Subutex side effects can include constipation, back pain, hoarseness of the voice, headache, nausea, painful urination, sleep problems or vomiting. Some of the less common but still possible Subutex side effects include diarrhea, feeling lightheaded or dizzy, flushing of ....
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