Hangzhou, the capital of Zhejiang Province, is the provincial center in Economy, Culture, Science and Education. It is a famous city in history and culture and also an important national tourist city with the beautiful scenery. Ribozymes are RNA-based enzymes that typically catalyze self-cleavage or splicing reactions. Liu et al. have now discovered hydrolytic endonucleolytic ribozymes (HYERs), which have the capability to precisely manipulate DNA.These ribozymes operate independently of proteins and can edit genes in both bacteria and human cells, offering a … Han Zhou. Han Zhou co-leads the Energy practice for Boston Consulting Group in China. She is a leading expert in chemicals for BCG in Greater China, and a core member of BCG’s Industrial Goods, Operations, and Global Advantage practices. Han has worked extensively with multinational and Chinese companies to help them develop growth strategies ... Han Zhou is a Research Assistant 2 MS at Yale School of Medicine. Dean’s Advisory Council on Lesbian, Gay, Bisexual, Transgender, Queer and Intersex Affairs Website Han Zhou. Han Zhou received his B.Sc. degree from the Harbin Institute of Technology, China, in 2016. He received his M.Sc. degree and Ph.D. degree from the Chalmers University of Technology, Sweden, in 2018 and 2023, respectively. In 2022, he was a visiting researcher at the IDEAS group, ETH Zurich. He is currently a postdoctoral researcher. View Han Zhou’s profile on LinkedIn, the world’s largest professional community. Han has 5 jobs listed on their profile. See the complete profile on LinkedIn and discover Han’s connections ... Dr. Jiajing Zhou. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria, 3010 Australia. Search for more papers by this authorHan (Warring States) (韓) (403–230 BC), a Chinese state during the Warring States period. Han dynasty (漢/汉) (202 BC–220 AD), a dynasty split into two eras, Western Han and Eastern Han. Shu Han (蜀漢) (221–263), a Han Chinese dynasty that existed during the Three Kingdoms period. Han-Zhao (漢趙) (304–329), one of the Sixteen ...D Liu, Y Han, H Zhou, H Jin, H Kang, F Huang, Y Liu, X Liang. Journal of Chromatography A 1640, 461935, 2021. 15: 2021: Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.Han Tuozhou ( Wade–Giles: Han T'o-chou; November 6, 1152 – November 24, 1207) was a Chinese politician of the Southern Song dynasty, who served as a chancellor under Emperor Ningzong . He was responsible for Southern Song efforts to recover territories lost in northern China to the Jurchen Jin dynasty in their 1142 peace settlement that ...The Xia–Shang–Zhou Chronology Project (Chinese: 夏商周断代工程; pinyin: Xià Shāng Zhōu Duàndài Gōngchéng) was a multi-disciplinary project commissioned by the People's Republic of China in 1996 to determine with accuracy the location and time frame of the Xia, Shang, and Zhou dynasties.. The project was directed by professor Li Xueqin of …Na Han. Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, 215123 China ... Yuan Zhou. Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and … A Systematic Study of Performance Disparities in Multilingual Task-Oriented Dialogue Systems. S Hu, H Zhou, M Yuan, M Gritta, G Zhang, I Iacobacci, A Korhonen, I Vulić. The 2023 Conference on Empirical Methods in Natural Language Processing (EMNLP) , 2023. 2. View Zhou Han’s profile on LinkedIn, a professional community of 1 billion members. Ph.D. neuroscientist and molecular biologist with 20 years of bench lab experience. Seven… In recognition of the exemplary efforts of Carolyn Szum, Chao Ding, Nan Zhou, Xu Liu, Han Li to build important relationships with industry to advance the science of data-driven, remote building energy analysis to improve building energy efficiency at speed and scale worldwide. Related Links: Chao Ding. Han Li.Han Zhou; Ignacio Iacobacci; Pasquale Minervini; In a task-oriented dialogue system, Dialogue State Tracking (DST) keeps track of all important information by filling slots with values given ...Han Zhou · Shuwang Li · Wenjun Ying Received: date / Accepted: date Abstract This paper is concerned with the mean curvature flow, which de-scribes the dynamics of a hypersurface whose normal velocity is determined by local mean curvature. We present a Cartesian grid-based method for solving mean curvature flows in two and three space dimensions.Oriental (Morocco) / 34.683°N 1.900°W / 34.683; -1.900. Oriental région or Oujda region ( Arabic: الشرق, romanized : aš-šarq) is one of the twelve regions of Morocco, …Zhou, Qin and Han Dynasties | World History | Khan Academy - YouTube. Fundraiser. Khan Academy. 8.07M subscribers. 848. 135K views 6 years ago 600 BCE - 600 CE Second-Wave Civilizations | …Han Tuozhou ( Wade–Giles: Han T'o-chou; November 6, 1152 – November 24, 1207) was a Chinese politician of the Southern Song dynasty, who served as a chancellor under Emperor Ningzong . He was responsible for Southern Song efforts to recover territories lost in northern China to the Jurchen Jin dynasty in their 1142 peace settlement that ...The Xia–Shang–Zhou Chronology Project (Chinese: 夏商周断代工程; pinyin: Xià Shāng Zhōu Duàndài Gōngchéng) was a multi-disciplinary project commissioned by the People's Republic of China in 1996 to determine with accuracy the location and time frame of the Xia, Shang, and Zhou dynasties.. The project was directed by professor Li Xueqin of …Dec 6, 2023 · The Zhou people had their origins in the far western reaches of the Yellow River in present day Shaanxi province. They conquered the Shang around 1050 B.C.E. and established their own dynasty. The Zhou shared many cultural similarities with the Shang. They performed similar religious rituals, used bronze ritual vessels, and practiced divination ... Background: In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. Methods: In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in …Rengui Li, Fuxiang Zhang, Donge Wang, Jingxiu Yang, Mingrun Li, Jian Zhu, Xin Zhou, Hongxian Han & Can Li Graduate University of Chinese Academy of Sciences, Beijing, 100049, China Rengui Li ...Han Zhou Communication Science Teaching Assistant. [email protected]. 608-263-3996. 6051 Vilas HallSubscribe to the channel: http://smarturl.it/BWFsubscribeThe BWF World Championships is held every year except for the year of an Olympic Games. It is a show...The Book of Han (Hàn Shū,《漢書》) is a history of China finished in 111 CE, covering the Western, or Former Han dynasty from the first emperor in 206 BCE to the fall of Wang Mang in 23 CE. [1] The work was composed by Ban Gu (32–92 CE), an Eastern Han court official, with the help of his sister Ban Zhao, continuing the work of their ...Han ZHOU. Title：Professor. Office：Room 335，Material Building D. Tel：+86-21-3420-2749. Email： [email protected]. Introduction. Prof. ZHOU’s research interests …Floquet Fractional Chern Insulators and Competing Phases in Twisted Bilayer Graphene. Peng-Sheng Hu, Yi-Han Zhou, Zhao Liu. We study the many-body physics in twisted bilayer graphene coupled to periodic driving of a circularly polarized light when electron-electron interactions are taken into account. In the limit of high driving …Managing Director & Partner. Shanghai. Han Zhou co-leads the Energy practice for Boston Consulting Group in China. She is a leading expert in chemicals for BCG in Greater …Han Zou, Yuxun Zhou, Jianfei Yang, Costas Spanos IEEE Internet of Things Journal, 2019 (IF=9.515) IOTJ Multiple Kernel Semi-representation Learning with Its Application to Device-Free Human Activity Recognition Han Zou, Yuxun Zhou, Reza Arghandeh, Costas Spanos IEEE Internet of Things Journal, 2019 (IF=9.515)Reconnue mondialement pour sa diversité et ses saveurs exceptionnelles , la cuisine du Maroc oriental propose une panoplie de plats. Des spécialités locales, traditionnelles, …Han Zhou; This study investigates the impact of oil price uncertainty on the cash holdings of firms. Using a sample of the Chinese stock market for the period from 2007 to 2016, our empirical ... ORCID record for Han Zhou. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities. Han-Ru ZhouThe design of electrode in liquid metal battery. a The overall workflow diagram, included the dataset, design loop, possible molar combinations, screening constraints and the LMBs with high specific energy. b Design loop has a main loop and a secondary loop, which comprises (i) dataset collection, (ii) feature selection, (iii) data ...In the Xia Dynasty (2070–1600 BC), top-bottom clothes prevailed. The basic form of the Hanfu was established in the Shang Dynasty (1600–1046 BC)…. The yi was a narrow-cuffed, knee-length tunic tied with a sash. The shang was a narrow, ankle-length skirt. Outside a knee-length apron or bixi (/bee-hsee/ 蔽膝 'cover the knees') was worn.ABSTRACT This paper establishes a quantitative model based on the system dynamics (SD) theory to reflect the ‘socioeconomic–water–environment’ coupling system and proposes three future development scenarios. Hubei province, China, is selected to verify this model. The simulation results from 2020 to 2030 demonstrate that the … 1.West Lake - the Legend of Hangzhou. West Lake is a symbol of Hangzhou. It is famous for its stunning scenery and various historical sites. It was selected as one of the "12 superb sunset spots around the world" by CNN. West Lake is gorgeous all year round. AU - Zhou, Yi-Han AU - Liu, Zhao AB - We study the many-body physics in twisted bilayer graphene coupled to periodic driving of a circularly polarized light when electron-electron interactions are taken into account. In the limit of high driving frequency $\Omega$, we use Floquet theory to formulate the system by an effective static …ORCID record for Han Zhou. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities.Han Zou, Yuxun Zhou, Jianfei Yang, Costas Spanos IEEE Internet of Things Journal, 2019 (IF=9.515) IOTJ Multiple Kernel Semi-representation Learning with Its Application to Device-Free Human Activity Recognition Han Zou, Yuxun Zhou, Reza Arghandeh, Costas Spanos IEEE Internet of Things Journal, 2019 (IF=9.515)View a PDF of the paper titled Appending Information Reconciliation for Quantum Key Distribution, by Han Zhou and 5 other authors. View PDF Abstract: Information reconciliation (IR), which corrects the errors in the sifted keys, directly determines the secure key rate and the link distance of quantum key distribution (QKD) …The long interval of power struggle that followed (475–221 bce) is known as the Zhanguo ( Warring States) period. China - Feudalism, Zhou Dynasty, Confucianism: The feudal states were not contiguous but rather were scattered at strategic locations surrounded by potentially dangerous and hostile lands. The fortified city of the feudal lord was ...Après le démarrage de la 1ère Cité des Métiers et des Compétences Souss Massa à Agadir, le 4 octobre dernier, celle de Nador accueille ce lundi 24 octobre 2022, … The founder of the Eastern Zhou, the King Ping of Zhou, was a son of the last Western Zhou ruler, the King You of Zhou; Western Han, Eastern Han, Shu Han, and Liu Song. The Western Han, the Eastern Han, the Shu Han, and the Liu Song were ruled by the House of Liu; the first two of which are collectively known as the Han dynasty The Shang dynasty was conquered by the people of Zhou, who came from farther up the Yellow River in the area of Xi’an in Shaanxi Province. In the first years of the Zhou dynasty (1046–256 B.C.), known as the Western Zhou (1046–771 B.C.), the ruling house of Zhou exercised a certain degree of “imperial” power over most of central China. We present LLaMA-Adapter, a lightweight adaption method to efficiently fine-tune LLaMA into an instruction-following model. Using 52K self-instruct demonstrations, LLaMA-Adapter only introduces 1.2M learnable parameters upon the frozen LLaMA 7B model, and costs less than one hour for fine-tuning on 8 A100 GPUs. Specifically, we …Dec 21, 2017 · The Han Dynasty ruled China from 206 B.C. to 220 A.D. and was the second imperial dynasty of China. Though tainted by deadly dramas within the royal court, it is also known for its promotion of... Dec 17, 2020 · Han Zhou, Yijing Sun, Zeyu Sun, Hengyang Zhao, and Sheldon X.-D. Tan. 2018. Electromigration-Lifetime Constrained Power Grid Optimization Considering Multi-Segment Interconnect Wires. In Proceedings of the 23rd Asia and South Pacific Design Automation Conference (ASP-DAC '18). IEEE Press, New York, NY, 399--404. Google Scholar Digital Library Han Tuozhou ( Wade–Giles: Han T'o-chou; November 6, 1152 – November 24, 1207) was a Chinese politician of the Southern Song dynasty, who served as a chancellor under Emperor Ningzong . He was responsible for Southern Song efforts to recover territories lost in northern China to the Jurchen Jin dynasty in their 1142 peace settlement that ...The Zhou Dynasty (1046-256 BCE) was among the most culturally significant of the early Chinese dynasties and the longest lasting of any in China's history, divided into two periods: Western Zhou (1046-771 BCE) and Eastern Zhou (771-256 BCE). It followed the Shang Dynasty (c. 1600-1046 BCE), and preceded the Qin Dynasty (221-206 BCE, …Biography. I am a second-year PhD student in Computation, Cognition, and Language (NLP) at Language Technology Lab, University of Cambridge. I am supervised by Prof. Anna Korhonen and Dr. Ivan Vulić. Previously, I … i10-index. 4. 4. Han Zhou. Chalmers University of Technology. Verified email at chalmers.se - Homepage. Power Amplifiers Integrated Circuit Design Milimeter-Wave RFIC & MMIC. Title. View Han Zhou’s profile on LinkedIn, a professional community of 1 billion members. Experience: Morgan Stanley · Education: University of California, Berkeley, Haas School of Business ... Shijie Han. Yumei Zhou. The aim of this study was to determine the dynamics of soil microbial biomass C, cellulose decomposition rate and catalase activity in Pinus koraiensis and Pinus ...Managing Director & Partner. Shanghai. Han Zhou co-leads the Energy practice for Boston Consulting Group in China. She is a leading expert in chemicals for BCG in Greater … Han Zhou; This study investigates the impact of oil price uncertainty on the cash holdings of firms. Using a sample of the Chinese stock market for the period from 2007 to 2016, our empirical ... Nador (Tamazight: ⵏⴰⴷⵓⵔ) is a coastal city and provincial capital in the northeastern Rif region of Morocco with a population of about 161,726 (2014 census).. Nador city is …This content has been updated on 18 March 2024 at 14 h 56 min. Han-Ru Zhou is an Associate Professor of Public Law at the Université de Montréal and an Associate Research Fellow at the Institute of Commonwealth Studies (University of London). He is a past Visiting Professor at the University of Ottawa, Visiting Scholar at the uOttawa Public ...Gillat av Han Zhou. Erfarenhet: Chalmers University of Technology · Plats: Göteborg · 500+ kontakter på LinkedIn. Visa Han Zhous profil på LinkedIn, ett yrkesnätverk med 1 miljard medlemmar.Han Zhou; This study investigates the impact of oil price uncertainty on the cash holdings of firms. Using a sample of the Chinese stock market for the period from 2007 to 2016, our empirical ...Advanced Materials, one of the world's most prestigious journals, is the home of choice for best-in-class materials science for more than 30 years.Somehow I pulled of an A in multi all thanks to Han. Han Zhou is a professor in the Mathematics department at University of Connecticut - see what their students are saying about them or leave a rating yourself.Han Zhou 0001 — Hebei University of Technology, Institute of Mathematics, Tianjin, China (and 2 more) Han Zhou 0002 — University of California at Riverside, Department of Electrical and Computer Engineering, CA, USA. Han Zhou 0003 — McMaster University, Department of Electrical and Computer Engineering, Hamilton, Canada (and 1 more ... View Han Zhou’s profile on LinkedIn, the world’s largest professional community. Han has 5 jobs listed on their profile. See the complete profile on LinkedIn and discover Han’s connections ... Han Zhou synes godt om dette. ₹. My academic journey began with an undergraduate degree in composites and a thesis on graphene/fluorocarbon composite coatings. During this time, I honed my skills in material testing and characterization and gained valuable experience in material preparation and analysis. My master's degree further solidified ...Subscribe to the channel: http://smarturl.it/BWFsubscribeThe BWF World Championships is held every year except for the year of an Olympic Games. It is a show...The current position of XIN HANG ZHOU is at South East Asia reported 11 hours ago by AIS. The vessel is en route to CN NSH, sailing at a speed of 14.8 knots and expected to arrive there on Apr 25, 02:00.The vessel XIN HANG ZHOU (IMO 9523017, MMSI 414713000) is a Container Ship built in 2012 (12 years old) and currently sailing under …Han Zhou · Shuwang Li · Wenjun Ying Received: date / Accepted: date Abstract This paper is concerned with the mean curvature flow, which de-scribes the dynamics of a hypersurface whose normal velocity is determined by local mean curvature. We present a Cartesian grid-based method for solving mean curvature flows in two and three space dimensions. The founder of the Eastern Zhou, the King Ping of Zhou, was a son of the last Western Zhou ruler, the King You of Zhou; Western Han, Eastern Han, Shu Han, and Liu Song. The Western Han, the Eastern Han, the Shu Han, and the Liu Song were ruled by the House of Liu; the first two of which are collectively known as the Han dynasty Xiao-Han Zhou, …, Yu-Jun Zheng. The art of phishing: past, present and future. Computer Fraud & Security, Volume 2019, Issue 4, 2019, pp. 9-11. Adam Binks. Cost-sensitive payment card fraud detection based on dynamic random forest and …Zhou Yi Ran, born in Chongqing, is a Chinese singer and actor. He made his debut in 2017 as a member of Yi'an Music Club, a cross-dimensional music group. However, in 2018, he announced that he would be leaving the group. He began his acting career in 2018 with a support role in the movie, "Go Brother!" and he landed his first lead role in the ... Han Zhou Ronghong Jin An m-shapedspoof surface plasmon polaritons (SSPPs) structure as well as its application into end fire antenna with vertical polarization, low profile and compact size are ... Mar 1, 2024 · Han Zhou: Writing – review & editing, Project administration, Funding acquisition, Conceptualization. Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Bibtex: @inproceedings{yang2021learning, booktitle = {Proceedings of the IEEE International Conference on Computer Vision (ICCV)}, author = {Bangbang Yang and Yinda Zhang and Yinghao Xu and Yijin Li and Han Zhou and Hujun Bao and Guofeng Zhang and Zhaopeng Cui}, title = {Learning Object-Compositional Neural Radiance Field …Zhou HAN, Associate Principle Scientist | Cited by 1,232 | | Read 21 publications | Contact Zhou HANHan Zhou. MathSciNet. Ph.D. Universiteit Utrecht 2017. Dissertation: Numerical approximation of time-fractional differential equations. Mathematics Subject Classification: 65—Numerical analysis. Advisor 1: Jason E. Frank. Advisor 2: Paul A. Zegeling. No students known. If you have additional information or corrections regarding this ... Han Zhou; This study investigates the impact of oil price uncertainty on the cash holdings of firms. Using a sample of the Chinese stock market for the period from 2007 to 2016, our empirical ... Liked by Han Zhou. BD & Strategy @ Cargill Protein | Investing in Food & Ag Innovation · Experience: Cargill · Education: University of Minnesota - Carlson School of Management · Location ...Apr 18, 2024 · The Han dynasty was the second great imperial dynasty of China (206 BCE–220 CE), after the Zhou dynasty (1046–256 BCE). It succeeded the Qin dynasty (221–207 BCE). The Han dynasty had a dominant effect on Chinese history and culture, and its governmental, cultural, and technological achievements were emulated by the dynasties that followed. Socio-Economic Objectives. Expanding knowledge (2801) Energy transformation (1704) Environmentally sustainable energy activities (1705) Dr Shou-Han Zhou holds the position of Lecturer, Psychology within the Psychology at James Cook University (JCU) on the Townsville campus.Liked by Lihan Zhou. View Lihan Zhou’s profile on LinkedIn, the world’s largest professional community. Lihan has 5 jobs listed on their profile. See the complete profile on LinkedIn and discover Lihan’s connections and jobs at similar companies.Han Zhou. Chalmers University of Technology. Verified email at chalmers.se - Homepage. ... H Zhou, JR Perez-Cisneros, S Hesami, K Buisman, C Fager. IEEE Transactions on …
Han Zhou. Han Zhou co-leads the Energy practice for Boston Consulting Group in China. She is a leading expert in chemicals for BCG in Greater China, and a core member of BCG’s Industrial Goods, Operations, and Global Advantage practices. Han has worked extensively with multinational and Chinese companies to help them develop growth strategies ... . Lax to los cabos
It can be described as kind of a feudal system. There's multiple kingdoms who have allegiance to the Zhous and at multiple times they have difference degrees of autonomy …The Western Zhou and the Eastern Zhou were ruled by the House of Ji; they are collectively known as the Zhou dynasty; The founder of the Eastern Zhou, the King Ping of Zhou, was a son of the last Western Zhou ruler, the King You of Zhou; Western Han, Eastern Han, Shu Han, and Liu SongLiked by Han Zhou. BD & Strategy @ Cargill Protein | Investing in Food & Ag Innovation · Experience: Cargill · Education: University of Minnesota - Carlson School of Management · Location ...Han Zhou Ubiquitin (UB) is transferred through an E1‐E2‐E3 cascade to cellular proteins and encodes diverse signals such as proteasome degradation, subcellular trafficking, interacting with ...We present LLaMA-Adapter, a lightweight adaption method to efficiently fine-tune LLaMA into an instruction-following model. Using 52K self-instruct demonstrations, LLaMA-Adapter only introduces 1.2M learnable parameters upon the frozen LLaMA 7B model, and costs less than one hour for fine-tuning on 8 A100 GPUs. Specifically, we …Large Language Models Are Human-Level Prompt Engineers. Yongchao Zhou, Andrei Ioan Muresanu, Ziwen Han, Keiran Paster, Silviu Pitis, Harris Chan, Jimmy Ba. By conditioning on natural language instructions, large language models (LLMs) have displayed impressive capabilities as general-purpose computers.Dec 15, 2022 · Wei Si 1 , Lele Xiong 2 , Han Zhou 3 , Huimin Wu 2 , Zhe Liu 1 , Guoqiang Liu 4 , Yanfang Liu 3 , Aijin Shen 5 , Xinmiao Liang 6 Affiliations 1 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences ... Biography. I am a second-year PhD student in Computation, Cognition, and Language (NLP) at Language Technology Lab, University of Cambridge. I am supervised by Prof. Anna Korhonen and Dr. Ivan Vulić. Previously, I …Zhou, Qin and Han Dynasties | World History | Khan Academy - YouTube. Fundraiser. Khan Academy. 8.07M subscribers. 848. 135K views 6 years ago 600 BCE - 600 CE Second-Wave Civilizations | …The current position of XIN HANG ZHOU is at South East Asia reported 11 hours ago by AIS. The vessel is en route to CN NSH, sailing at a speed of 14.8 knots and expected to arrive there on Apr 25, 02:00.The vessel XIN HANG ZHOU (IMO 9523017, MMSI 414713000) is a Container Ship built in 2012 (12 years old) and currently sailing under …Zhou Dynasty (1047 BC-256 BC) The Zhou Dynasty was one of the most important dynasties in the history of China. ... Han Dynasty (206BC-220AD) The Han Dynasty was the second dynasty in Imperial China. It spanned over 4 centuries and is often referred to as China’s golden age.Portfolio site of Singaporean Photographer & Artist, Zhou HanShun. top of page. ZHOU HANSHUN. PHOTOGRAPHER & ARTIST. PROJECTS. 上海 Once Upon The Sea (2012 – 2019) Frenetic City (2014 – 2019) Ubin (2021) 7th Month Populace (2019 – ) The 7th Month (2018 – 2021) Abandoned Gods (2019)Han Zhou: Writing – review & editing, Project administration, Funding acquisition, Conceptualization. Declaration of competing interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper..